傳染性法氏囊病病毒（infectious bursal disease virus，IBDV）新型變異株正在我國(guó)廣泛蔓延，給商品肉雞群和蛋雞群帶來(lái)了新的威脅。本研究對(duì)一個(gè)疑似發(fā)生非典型傳染性法氏囊病的地方品種雪山草雞群進(jìn)行了RT-PCR檢測(cè)，并對(duì)分離的3株毒株進(jìn)行了基因測(cè)序及序列分析。結(jié)果顯示，引起該雞群發(fā)病的病原是IBDV新型變異株，屬于A2dB1基因型；這3個(gè)毒株的VP2高變區(qū)編碼蛋白上含有IBDV變異株的特征性氨基酸，也具有IBDV新型變異株的獨(dú)特氨基酸。結(jié)果提示，我國(guó)地方品種雞群中也有IBDV新型變異株的流行，現(xiàn)有的部分商品化IBDV疫苗已不能有效預(yù)防IBDV新型變異株的流行。
Identification of Novel Variant Strain of Infectious Bursal Disease Virus in Xueshan Chicken
Novel variant strains of infectious bursal disease virus（IBDV）have been spreading widely in China，posing a new threat to commercial broilers and layers. In the study，a local variety of Xueshan chicken with suspected atypical IBD was detected by RT-PCR，gene sequencing and sequence analysis were then conducted for the three isolates. The results showed that the disease was caused by novel variant strain of IBDV that belongs to A2dB1 genotype；in addition to the characteristic amino acids of variant strain，the unique amino acids of novel variant IBDV were also contained in the hypervariable region of VP2 encoding proteins of the three isolates. It was indicated that the novel variant IBDV could not be effectively controlled by some current commercial vaccines，as it has been spreading in local chicken in China.
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